The town of Chester's Mill, Maine is suddenly cut off from the outside world when an invisible barrier comes down, trapping everyone inside. Many injuries and fatalities occur during the first day (plane crash, multiple car crashes, Duke's pacemaker explodes). Jim Rennie, the town's second selectman(who already has a significant influence over the town), uses the barrier as a way to rise to power and rule over the town. Rennie expands the police force by employing his son(who suffers from excruciating migraines from an undiscovered brain tumor) and his reckless friends. Life under the dome changes significantly in just a few days.
While the government is unsuccessful in trying to break through the dome (using cruise missiles and deadly chemicals), Jim Rennie is manipulating the town in believing that he is doing everything that he can for the town, when he's actually running the largest drug lab on the east coast. A few individuals who cross his path throughout are framed, blackmailed, and even murdered. Dale Barbara, Julia Shumway, and a few others try to find a way to stop Rennie (who is enjoying his power and influence under the dome) and find out what or who is keeping them trapped.
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